Serum Level of Vascular Endothelial Growth Factor in Patients with Different Clinical SubtypeS of Oral Lichen Planus
نویسندگان
چکیده
BACKGROUND Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal individuals and consider its clinical significance. METHODS In this case-control study, 36 serum samples from patients diagnosed with oral lichen planus admitted to the Oral Medicine Department of the School of Dentistry at Shiraz University of Medical Sciences (14 men, 22 women, mean [±SD] age: 38.8 [±6.07] years) and 23 serum samples from healthy individuals (9 men, 14 women, mean [±SD] age: 38.7 [±4.9] years) were collected. VEGF concentration was measured using the ELISA method. The Mann-Whitney test was used for statistical analysis. RESULTS The serum VEGF level was significantly higher in patients with oral lichen planus compared with the healthy controls (112.97 [±63.2] vs. 66.21 [±56.2] ngr/ml, P<0.001). A similar difference was also observed between the two types of oral lichen planus, being more pronounced in the erosive form (P<0.001). CONCLUSION Serum VEGF can be used as a useful and suitable marker to scrutinize the disease activity.
منابع مشابه
Serum Level of Vascular Endothelial Growth Factor in Patients with Different Clinical SubtypeS of Oral Lichen Planus
Background: Oral lichen planus is a chronic inflammatory disease with a poorly understood etiology. The role of angiogenesis in the development of different chronic inflammatory diseases is of great concern. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis. We aimed to evaluate the serum level of VEGF in patients with oral lichen planus compared with normal in...
متن کاملVascular Endothelial Growth Factor Level in Patients With Oral Lichen Planus: A Systematic Review and Meta-Analysis Study
Background: According to the possible role of Vascular Endothelial Growth Factor (VEGF) in the incidence of oral lichen planus lesions, it seems necessary to evaluate it in patients with Oral Lichen Planus (OLP). Objective: The present study aims to investigate the level of VEGF in patients with OLP. Methods: In this systematic review and meta-analysis study, the search was conducted in online...
متن کاملVascular Endothelial Growth Factor in Serum and Saliva of Oral Lichen Planus and Oral Squamous Cell Carcinoma Patients
Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was pe...
متن کاملVascular Endothelial Growth Factor Expression in Oral Lichen Planus: A Comparative Study
Background and aim: Lichen planus (LP) is a chronic inflammatory disease with an uncertain pathogenicity. Recent reports have revealed that angiogenesis is effective in the pathogenesis and biologic behavior of lesions. Considering the limitations of the studies related to angiogenesis in oral LP (OLP) and the controversial results, the present study aimed to compare the expression of vascular ...
متن کاملPnm-9: Serum and Peritoneal Fluid Level of Vascular Endothelial Growth Factor in Endometriosis
Background: Endometriosis is known as one of the most common disease in women of reproductive age. Due to importance role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell and different reported results for VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 37 شماره
صفحات -
تاریخ انتشار 2012